Endocrine Abstracts

The control of acromegaly with drug therapy (DT) by fg-SRLs is achieved only in 40–50% of cases, due to the heterogeneous composition of somatotrophic tumors. In order to optimize DT stratification of clinical and immunophenotypic biomarkers which make it possible to predict the long-term effectiveness of fg-SRLs at early stages is required. The aim of the work was to assess the informativeness of pharmacotherapeutic testing (% of decrease of IGF-1 level after 3 and 6 mon...

The aim: To determine the prognostic parameters affecting the course of acromegaly (A.) and the effectiveness of drug therapy (MT).Matherials and methods: 779 patients of A. [218 men (28%)] aged 60 (48/69) years, [Me(25%/75%)] were included in the Moscow register. The prevalence of A. in Moscow is 61.6; the incidence is 4.0 cases/million inhabitants. The treatment algorithm included surgical aid (495 patients), primary (I) or secondary (II) MT (584) and ...

Taking into account heterogeneity of somatotrophic tumors (STs), intragroup differential diagnostics is of practical importance, since it allows to predict scenario of acromegaly clinical course, as well as the efficacy of secondary drug therapy (DT).The aim of this study was to determine prognostic power of cytological, immunological&radiological predictors of sensitivity/resistance to fg-SRLs in patients with pure somatotropinomas.Materials and Met...